Indianapolis Colts open as Biggest NFL Week 1 favorite Houston Texans

We’re four whole months away from the start of the 2022 NFL regular season, but its arrival is beginning to feel more real all the time.

Last week, the NFL released its schedule for each team, and it was revealed that the Indianapolis Colts will open their season on the road against an AFC South matchup against the Houston Texans.

The gambling community was on the ball and has already opened betting lines for Week 1 of the regular season. They feel the Colts are entering a lopsided battle, giving them the best odds of the week as 8-point road favorites.

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